5 steps to achieve a successful pregnancy

According to the WHO, infertility is a public health issue that currently affects more than 40 million couples worldwide. And it seems that the number is increasing. Could it be related to our current lifestyle?

If you’ve been on this page before or follow us on social media, you know that stress can be an important factor in hormonal imbalance in women.
This stress—both psychological and biological—can disrupt your hypothalamic-pituitary-adrenal (HPA) axis. In other words, cortisol will prevent your hypothalamus from sending the signal to your pituitary gland to produce the hormones responsible for ovulation and fertilization (Soledad Gualdrás, 2021).

And if that biological stress comes from a leaky gut, you may have deficiencies in specific micronutrients that should help you maintain a healthy pregnancy and reduce the risk of miscarriage.

Below we share 5 steps to help you improve your fertility:

Step One: Apply the 3R Protocol of Immunonutrition to Heal Leaky Gut‍

Your gut is the entry point—not only does it digest and absorb the micronutrients we’ll detail below, but it is also the main hub of your immune system, as 80% of your body’s defenses are located there. If you follow a gut-friendly and easy-to-digest diet, nutrient absorption will improve.
In this article, we detail the 3Rs of NutriWhite that you can start applying today.

Step Two: Identify and Remove Non-Celiac Gluten Sensitivity as a Cause of Miscarriage‍

One of the most common causes of leaky gut is non-celiac gluten sensitivity. When it causes inflammation and gut permeability, it disrupts your hormones, including your female hormones.
You can take genetic tests to identify this.

Below we share some studies:

1. Cytokines Profile in Treated Celiac Disease Compared with Non-celiac Gluten Sensitivity and Control: a Marker for Differentiation. Fatemeh  Heydari, Mohammad  Rostami-Nejad,  Ali  Moheb-Alian,  Mostafa  Haji  Mollahoseini,  Kamran  Rostami, Mohamad Amin Pourhoseingholi, Elham Aghamohammadi, Mohammad Reza Zali SerumDOI:  http://dx.doi.org/10.15403/jgld.2014.1121.273. 
2. Do celiac disease and non-celiac gluten sensitivity have the same effects on reproductive disorders? Nutrition. 2018 Apr;48:18-23. doi: 10.1016/j.nut.2017.11.022. Epub 2017 Dec 8. Pieczyńska J. PMID: 29469015.  
3. Navigating the Challenges of Gluten Enteropathy and Infertility: The Role of Celiac-Related Antibodies and Dietary Changes. Antibodies (Basel). 2023 Dec Peshevska-Sekulovska M, Gulinac M, Rangelov R, Docheva D, Velikova T, Sekulovski M. 6;12(4):79. doi: 10.3390/antib12040079. PMID: 38131801; PMCID: PMC10741221.

Step Three: Identify 5 MTHFR‍

The 5 MTHFR is the gene responsible for transporting dietary folate to your receptors so you can absorb it. However, if you have a mutation or SNP in this gene, it will be difficult for you to absorb this vitamin in its synthetic form, that is: folic acid.

The active form of this vitamin is folinic acid or 5-methyltetrahydrofolate (5 MTHF). This vitamin is also KEY when it comes to conception and maintaining a pregnancy.

The following studies will provide you with more information:

4. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJ R Assist Reprod Genet. 2018 Aug;35(8):1431-1435. doi: 10.1007/s10815-018-1225-2. Epub 2018 Jun 7. PMID: 29882091; PMCID: PMC6086798. 
5. Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles. Biomolecules. 2022. Menezo Y, Elder K, Clement A, Clement P. Jan 24;12(2):197. doi: 10.3390/biom12020197. PMID: 35204698; PMCID: PMC8961567. 
6. Serum 5-Methyltetrahydrofolate Status Is Associated with One-Carbon Metabolism-Related Metabolite Concentrations and Enzyme Activity Indicators in Young Women. Kubo Y, Shoji K, Tajima A, Horiguchi S, Fukuoka H, Nishikawa M, Kagawa Y, Kawabata T.Int J Mol Sci. 2023 Jul 1;24(13):10993. doi: 10.3390/ijms241310993. PMID: 37446171; PMCID: PMC10341762. 

Step Four: Evaluate the Thyroid as a Cause of Miscarriages‍

Thyroid hormones control various functions of your metabolism. In addition to your body weight, they regulate your temperature, mood, bowel movements, and certain functions of your female hormones.

The following studies will provide you with more information:

7. Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis. Thyroid. 2016 Apr;26(4):580-90.Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM. doi: 10.1089/thy.2015.0418. Epub 2016 Mar 3. PMID: 26837268; PMCID: PMC4827301. 
8. Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study. J Pregnancy. 2015;2015:132718. Feldthusen AD, Pedersen PL, Larsen J, Toft Kristensen T, Ellervik C, Kvetny J. doi: 10.1155/2015/132718. Epub 2015 Aug 17. Erratum in: J Pregnancy. 2017;2017:9864034. PMID: 26351582; PMCID: PMC4553340. 
9. Implantation failure in rats with subclinical hypothyroidism is associated with LIF/STAT3 signaling. Shan L, Zhou Y, Peng S, Wang X, Shan Z, Teng W. Endocr Connect. 2019 Jun;8(6):718-727. doi: 10.1530/EC-19-0185. PMID: 31063977; PMCID: PMC6547307. 

Step Five: High-Dose CoQ10 for Egg Quality‍

Ubiquinol is the active form of CoQ10, a powerful antioxidant that is also key to improving the quality of your eggs.

The following studies will provide you with more information:

10. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A.Oct;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26. PMID: 26111777; PMCID: PMC4568976. 
11. Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Oocyte Through a Network Pharmacology Approach. Front Endocrinol (Lausanne). 2022 Feb 11;13:813772. Yang L, Wang H, Song S, Xu H, Chen Y, Tian S, Zhang Y, Zhang Q.  doi: 10.3389/fendo.2022.813772. PMID: 35222272; PMCID: PMC8874996.
12. Aging and the environment affect gamete and embryo potential: can we intervene? Fertil Steril. 2016 Mar;105(3):548-559. Meldrum DR, Casper RF, Diez-Juan A, Simon C, Domar AD, Frydman R. doi: 10.1016/j.fertnstert.2016.01.013. Epub 2016 Jan 23. PMID: 26812244. 

As you can see, there are several steps you can take to achieve a successful pregnancy! And depending on your specific condition, the root of your symptoms, your lifestyle, and your preferences, you may need to focus more on one area in particular.

We even recommend involving your partner in this anti-inflammatory lifestyle so that both of you can benefit.

So, in addition to doing your tests and evaluating your fertile days calendar with your partner, we want to be there for you to provide the tools you need in your personalized NutriWhite ONLINE Consultation with our team of specialists!

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